Rosmarinic Acid Prevents Cisplatin-Induced Liver and Kidney Injury by Inhibiting Inflammatory Responses and Enhancing Total Antioxidant Capacity, Thereby Activating the Nrf2 Signaling Pathway.

Molecules · 2022 · PMC9695501 · PMID 36431915

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highly significantp < 0.01actually significant

After administration of the RA pretreatment, hepatic and renal IL-1β, IL-6, and TNF-α mRNA expression levels showed a significant downregulation ( p < 0.01) and SOD, CAT, and GPx mRNA expression levels showed a highly significant upregulation ( p < 0.01) compared to CP induction alone.

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