highly significantp = 6.1 × 10 −12
The difference in GC% between genes with decreased TE in ATRA and insensitive genes was highly significant ( p = 6.1 × 10 −12 ) and a difference in the distribution of GC% from genes with increased TE was also notable compared with the insensitive pool ( p = 5.2 × 10 −5 ; Figure 4 E).