Mitochondrial Alterations in Neurons Derived from the Murine AppNL-F Knock-In Model of Alzheimer's Disease.

J Alzheimers Dis · 2022 · PMC9697055 · PMID 36155507

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0.0694

closest p · 1.4× alpha

0.0850

boldest claim

The sentences

almost significantp = 0.0694so close (0.05 < p ≤ 0.1)

Surprisingly, App NL - F cell showed a significant increase in basal respiration ( p = 0.0177, Mann-Whitney test), maximal respiration ( p = 0.0076, Mann-Whitney test), ATP-linked respiration ( p = 0.0177, Mann-Whitney test), and almost significant spare respiratory capacity ( p = 0.0694) compared to WT cells ( Fig. 2B, C ), unlike previously reported in A β PP overexpressing models including APP Swe/Lon overexpressing cell lines, APP Swe/Lon transgenic mice whole brains and isolated mitochondria [ 15, 16 ].

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almost significantlyp = 0.085so close (0.05 < p ≤ 0.1)

2I ); similarly, glycolytic capacity was almost significantly downregulated in App NL - F neurons ( p = 0.085) ( Fig. 2I ).

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