Barely Significant
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Healthcare Worker Study Cohort to Determine the Level and Durability of Cellular and Humoral Immune Responses after Two Doses of SARS-CoV-2 Vaccination.

Vaccines (Basel) · 2022 · PMC9697204 · PMID 36366293

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a positive trendno p-value reported
The Spike-specific CD4+ T cell response did not show incremental differences between one or two vaccine doses, although a positive trend was observed in the group of subjects without previous infection.

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