Insights into Antimalarial Activity of <i>N</i>-Phenyl-Substituted Cinnamanilides.

Molecules · 2022 · PMC9698057 · PMID 36431900

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an increasing trendno p-value reported

Based on Figure 3 a, it can be stated that compounds substituted in positions C (3) ′, C (3,4) ′, or C (3,5) ′ displayed an increasing trend of activity with the lipophilicity increasing up to compound 21 (R = 3-F-4-Br, log k ca. 0.5), after which the activity increases insignificantly.

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