EBV-seropositive healthy individuals show a nonsignificant trend toward increased ABC proportions compared to EBV-seronegative healthy people but reduced compared to RRMS ( Fig. 5B ).
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Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS.
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Regulatory T cells displayed an increasing trend in KO mice in both EAE and γHV68-EAE mice, indicating that ABCs may dampen the regulatory T cell population during autoimmunity ( Fig. 3D ).