MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis.

Of note, genome-wide association studies have identified the 9p21.3 locus as one of two highly significant regions that are broadly associated with multiple age-related pathologies, the other key region coinciding with the HLA locus on chromosome 6p21 (ref. 24 ).

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