The spectrum of plasma renin activity and hypertension diseases: Utility, outlook, and suggestions.

On the other hand, some evidence indicates that there is a highly significant correlation between PRA and DRC results. 14 , 15 Renin is the upstream component of the renin‐angiotensin‐aldosterone system (RAAS), which contains 340 amino acid residues (37 kDa) and is released from renal juxtaglomerular cells. 16 Renin acts as an aspartate proteolytic enzyme to specifically hydrolyze AGT, which is synthesized by the liver. 17 , 18 The product, decapeptide Ang1, has very minimal biological activity and is easily degraded by nonspecific proteases into angiotensin peptide products (Figure 1 ).

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