The Rheb GTPase promotes pheromone blindness via a TORC1-independent pathway in the phytopathogenic fungus Ustilago maydis.

This point is according to me highly significant, and the authors should provide strong arguments defending why this strategy is still appropriate (or alternatively provide further data to circumvent this issue). • The authors have conducted several immunoprecipitation (IP) experiments and evidenced changes in the phosphorylation status as readouts for TORC1-dependent and -independent pathways.

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