The simultaneous interference with both IFN-γ and IL-12 signaling led to the selective a nd highly significant reduction of Th2/1 hybrid cells in blood as well as small intestine without affecting the accumulation of classical GATA-3+ Th2 cells or the numbers of Th1 cells in the infected gut (Fig. 2a, b ).
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Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.
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