Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia.

Leukemia · 2022 · PMC9712081 · PMID 36369483

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

verged on significanceP = 0.06so close (0.05 < p ≤ 0.1)

To an extent that verged on significance, SBS18 contributed more to oncogenesis than to mutational burden ( P = 0.06, two-sample Wilcoxon signed-rank test).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.