Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with ^99mTc and ¹²⁵I.

The blocking test showed that the pre-treatment of SK-RC-52 renal carcinoma cells with a large excess of unlabeled Ec1 resulted in a highly significant (P<0.00005) reduction in binding for both radiolabeled DARPins ( Fig. 1 ).

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