Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines.

DNMT1 copy number showed a weak trend for association with sensitivity to PI-103 and THZ-2-102-1, whoever it did not reach the threshold of | ρ | > 0.3 ( ρ = − 0.256 and − 0.268, respectively; Additional file 7 : Table S4).

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In contrast, we found a strong and highly significant correlation between copy number and expression levels of HM13 in our analysis (Spearman ρ = 0.585, p 0 = 1.67 × 10 –58 , Pearson r = 0.518, p 0 = 5.14 × 10 –44 ; Fig. 2 C).

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