Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation.

J Gen Physiol · 2023 · PMC9723511 · PMID 36459134

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may be significantno p-value reported

It may be significant that pseudo-repeat 4 contains non-canonical Asp137 that can provide coiled-coil tropomyosin with enhanced local torsional flexibility to facilitate such movement ( Lehman et al., 2020 ).

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