Barely Significant
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The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency.

Nanoscale Adv · 2022 · PMC9724609 · PMID 36540111

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may not be significantno p-value reported
First, the difference between 40 and 50 nm may not be significant enough for varying the uptake patterns of the cells.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.