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Glucocorticoid therapy in respiratory illness: bench to bedside.

J Investig Med · 2022 · PMC9726965 · PMID 35764344

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may be significantno p-value reported
22 It is well known that GCs inhibit the mRNA transcription of proinflammatory genes, which may be significant to reducing neutrophilic inflammation due to evidence that lung-transmigrated neutrophils exhibit a rapid burst of inflammatory transcription on arrival in the airspace. 137 However, GCs have generally failed to show efficacy in ALI/ARDS in human clinical studies. 138 Indeed, the influence of GCs in infection-induced acute injury appears pathogen-dependent.

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