highly significantp < 0.001
The decrease from 1995 to 2019 was highly significant for 1-OH-Pyr (p < 0.001) and 1-Nap (p < 0.001).
The decrease from 1995 to 2019 was highly significant for 1-OH-Pyr (p < 0.001) and 1-Nap (p < 0.001).
Nevertheless, urinary Cot excretion in our study was slightly higher in the early 2000s compared to NHANES; however, a decreasing trend was also observed in the U.S. population over time ( CDC, 2019 ).