Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration.

The observed hypsochromic shift of EMW by 10 to 20 nm over the development of pathology from very nonuniform RPE to intraELM cells agrees well with a highly significant 12 nm difference of the peak emission wavelength between aged healthy subjects and patients with AMD, observed in vivo by FLIO. 34 Several pathways of RPE cell activation leading to complete RPE and outer retinal atrophy (cRORA), have been described by OCT and histology. 6 , 15 , 16 A healthy RPE layer shows polygonal cells of nearly uniform thickness.

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