Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.

In line, MB expression in the adult cohort showed highly significant correlations not only with UCP1 but also with additional markers of AT browning, including TMEM26 , UCP3 and NRG4 36 , 37 in SC AT ( n pairs = 1 473; UCP1: ρ Spearman = 0.39; p = 1.26 × 10 −53 , Figure 9G ; TMEM26: ρ Spearman = 0.21, p = 1.12 × 10 −15 ; UCP3: ρ Spearman = 0.51, p

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