Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.

As shown in representative blots and summary results, the expression of NOS3 and SOD2 showed an increasing trend in SU/Hx/Nx as compared to SU/Nx G6PD S188F rats ( Fig. 4 , F and G ), while expression of SERPINE1 showed increasing trend in SU/Hx/Nx as compared with SU/Nx WT and G6PD S188F rats ( Fig. 4 , F and G ).

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While there was a decreasing trend in posttranslation modification spectrum counts between SU/Nx G6PD S188F and WT rats ( Fig. 5 D ).

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