Barely Significant
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Estradiol and Testosterone Concentrations Among Thai Transgender Women in a Transgender-Led, Integrated Gender-Affirming Care and Sexual Health Clinic: A Real-World Analysis.

Transgend Health · 2022 · PMC9734012 · PMID 36514686

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a positive trendno p-value reported
During a 12-month follow-up period, both E2 and TT showed a positive trend toward target concentrations, and approximately half were able to achieve or maintain at least one hormone concentration within target ranges, suggesting a positive effect from attending a comprehensive transgender-specific health care facility.

also in 11,005 other papers

a decreasing trendno p-value reported
an increasing trendno p-value reported
Overall, there was an increasing trend of E2 concentrations and a decreasing trend of TT concentrations toward target concentrations during follow-up visits ( Fig. 1 ).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.