<i>Post Mortem</i> Study on the Effects of Routine Handling and Manipulation of Laboratory Mice.

Traumatic osteoarticular lesions were found in 61 heavily manipulated mice, and in a single unmanipulated mouse, showing a highly significant association between the presence of traumatic osteoarticular lesions and heavy handling of mice.

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While an overall trend towards increased traumatic osteoarticular lesion frequency in older animals was observed, statistical significance was not reached, even after stratification based on strain and sex ( Supplementary Material Figure S1 ). 3.3.

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