Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.

The enrichment of cellular components from gene ontology (GO) ranked terms such as “extracellular exosome”, “extracellular vesicle”, “extracellular membrane-bounded organelle”, “extracellular organelle” and “extracellular space” ( Figure 2 e) with highly significant p -values, confirming the overall efficient EV enrichment ( Table S2 ).

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