Morphological, biochemical, and transcriptomic characterization of iPSC-derived human RPE cells from normal and Smith-Lemli-Opitz syndrome patients.

Mol Vis · 2022 · PMC9744241 · PMID 36540063

Europe PMC

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Based on the pathway analysis, “response to oxidative stress” was identified as a highly significant pathway that is dysregulated in A2 RPE ( Figure 3 ), which may be a result of the increased levels of 7DHC (a highly oxygen-labile organic compound) observed in the sterol quantification studies.

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