Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis.

To replicate the CF lung environment, isolates were also grown in the presence of 5% pooled CF sputum supernatant and then treated with tobramycin; again, the biovolume of eradicated isolates was significantly reduced and there was a nonsignificant trend (p = 0.05) to significant reduction in the persistent isolates (Fig. 5 A).

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