Neuroplasticity of the Lateral Geniculate Nucleus in Response to Retinal Gene Therapy in a Group of Patients with <i>RPE65</i> Mutations.

7 Additionally, Pearson correlations ( Figure 3 ) between the incremental changes in the left and right LGN volumes, before and one year after retinal gene therapy, and the incremental changes in the patients’ Golmann visual field measures for the same time period showed a positive trend with the changes in the left LGN reaching statistical significance (see Figures 3A and B ), demonstrating the effect of LGN volume increase on the patients’ clinical response.

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