The few in vitro experiments mentioned demonstrated that SphK1b expression reduces drug sensitivity in hormone-responsive prostate cancer cells, suggesting that the expression of SphK1a and 1b in prostate cancer patients may be significant in the selection of treatment with the potential to desensitize hormone treatment response [ 33 , 35 , 36 ].
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Expression Profile of Sphingosine Kinase 1 Isoforms in Human Cancer Tissues and Cells: Importance and Clinical Relevance of the Neglected 1b-Isoform.
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