highly significantp values = 4.61 × 10 −8
2B ) that among the top ten enriched pathways, five of them exhibited highly significant enrichment p value for the 3 treatments (digoxin 1 μM, digoxin 10 μM, and TNFα 30 ng/ml): HIF-1 targets ( p values = 4.61 × 10 −8 , 5.61 × 10 −5 and 2.06 × 10 −7 ), glycolysis and gluconeogenesis ( p values = 5.06 × 10 −7 , 4.43 × 10 −3 and 2.43 × 10 −5 ), antigen presentation by MHC class I ( p va