Global Patterns and Trends in Total Burden of Hepatitis B from 1990 to 2019 and Predictions to 2030.

Clin Epidemiol · 2022 · PMC9760077 · PMID 36540899

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a decreasing trendno p-value reported

33 , 34 In addition, it was important to note that although the global ASMR showed a decreasing trend, the number of HBV-related deaths was on the rise, from 524.5 (95% UI 468.3–585) ×10^3 in 1990 to 555.5 (95% UI 487.1–630.1) ×10^3 in 2019 ( Table S2 ), due to the population growth and aging. 35 Several limitations of this study should be noted.

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