Understanding protein diffusion on force-induced stretched DNA conformation.

In contrast, the number of sliding events exhibits an increasing trend in the high-force regime, the rationale of which arises from the increased protein–DNA electrostatic energy due to the increased separation distance between phosphate groups, which helps the protein not to slide too long on DNA, and a right blend of the combination of 1D and 3D search modes accelerates the diffusing protein for the faster recognition of DNA bases on stretched DNA.

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Other probabilities (from p 4 to p 10 ) exhibit a decreasing trend with F ( Figure 3C and Supplementary Figure S6 ), mainly because of the too-high backbone strain for higher-order base-pair clusters.

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