Metabolomics identifies shared lipid pathways in independent amyotrophic lateral sclerosis cohorts.

Brain · 2022 · PMC9762943 · PMID 35088843

Europe PMC DOI

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highly significantno p-value reported

Subnetwork S3 comprised free long-chain fatty acids of all saturation levels (saturated, monounsaturated, polyunsaturated; highly significant), which were universally elevated in ALS participants.

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an overall trendno p-value reported

When we sorted ALS participants by ALSFRS-R from high to low score, this generated an overall trend of decreasing metabolites with worsening ALS status.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.