a nonsignificant trendP = .074
When we compared variant takeover to estimated immunity from vaccination alone, there was no relationship between immunity and takeover rates, a statistically significant delay in Delta takeover date ( P = .01) and time from establishment to dominance ( P = .011) for Omicron in states with higher vaccine-induced immunity, and a nonsignificant trend to delayed takeover date for Omicron in more vaccinated states ( P = .074) ( Supplementary Figure S3 ).