Barely Significant
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Beta-blockers in post-acute myocardial infarction patients: Drug prescription patterns from 2018 to Italy's first wave of the COVID-19 pandemic.

Front Pharmacol · 2022 · PMC9768333 · PMID 36569305

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a decreasing trendno p-value reported
Rates were higher in 2018, then highlighting a decreasing trend over time.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.