SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants.

Correlation analysis revealed that the titer of total NAbs correlated with that of 13G2 or 08B3 in I-I-δ, I-I-ο, and I-I-I, even though the former two groups showed a decreasing trend of correlation for WT, Delta, and Omicron variants and the latter one group did not.

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Furthermore, only the M-M-ο group showed an increasing trend in the proportion of RBD + IFN-γ + CD4 + T cells (Fig. 3b ) and a higher percentage of IFN-γ + CD4 + T cells among virus-specific CD4 + T cells; no notable difference was seen between the groups (Fig. 3c ).

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