Major histocompatibility antigens exert the strongest effect on transplanted tissues, while the many minor histocompatibility antigens, such as blood group substances and the secretory alloantigen system, have a weaker, although often highly significant role in graft rejection. h. genes genes that code for the histocompatibility antigens. major h. complex (MHC) a cluster of loci on one autosomal chromosome containing the genes that code for the major histocompatibility antigens.
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