Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice.

Indeed, there was a highly significant correlation between B cell influx and tumor regression over time ( figure 5F ). 10.1136/jitc-2022-005345.supp8 Supplementary data Depletion of B cells interferes with anti-CTLA-4-mediated eradication of liver metastases The presence of TLS and B cells predicts the response of metastatic melanoma and sarcoma to immune checkpoint inhibitors. 14–16 However, empirical evidence for their contribution to treatment efficacy in these and other cancer types is currently lacking.

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