Synthesis, characterization, and anticancer evaluation of 1,3-bistetrahydrofuran-2yl-5-FU as a potential agent for pancreatic cancer.

BMC Cancer · 2022 · PMC9773620 · PMID 36550419

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a decreasing trendno p-value reported

an increasing trendno p-value reported

We investigated the expression of BCL-XL, BAX, and Caspase-9; we obtained a decreasing trend in BCL-XL expression, while an increasing trend was observed in the expression of BAX and Caspase-9, indicating apoptosis was the mechanism of cell death through the activation of mitochondria (intrinsic) pathway of apoptosis.

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