Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population.

PLoS One · 2022 · PMC9778564 · PMID 36548255

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0253

boldest claim

The sentences

highly significantp = 1.21 x 10 −05actually significant

A highly significant protective effect for HLA-A*02 : 01 was observed in females (OR = 0.63, p = 1.21 x 10 −05 ), while no effect was seen in males ( Table 4 ).

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marginal significancep = 2.53 x 10 −02actually significant

We did not find significance for the previously identified African allele, HLA-DRB1*15 : 03 at the pre-specified significance level of 1.0 x 10 −04 ; however, after conditioning on the three independent African classical alleles, marginal significance was seen (OR = 1.23, p = 2.53 x 10 −02 ), indicating that HLA-DRB1*15 : 03 does contribute to MS risk within this sample.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.