TRIAC Treatment Improves Impaired Brain Network Function and White Matter Loss in Thyroid Hormone Transporter Mct8/Oatp1c1 Deficient Mice.

Our network-based statistics (NBS) analysis including 94 brain regions of the Allen Brain Atlas (atlas.brain-map.org, regions illustrated in Figure 1 B) provides evidence for a highly significant ( p < 0.002) increase of functional connectivity (FC) on the whole-brain network level in the Mct8/Oatp1c1 DKO group compared to WT mice ( Figure 3 A, primary threshold of p pt < 0.01, NBS permutation test with 5.000 runs and p NBS < 0.025).

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