The International Study of Asthma and Allergies in Childhood (ISAAC), the largest worldwide collaborative research project, showed that there was a wide global variation in the prevalence of asthma, allergic rhinitis (AR), and eczema with an increasing trend in developing countries and reaching a plateau in developed countries from the mid-1990s to the early 2000s [ 6 ].
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Childhood Wheeze, Allergic Rhinitis, and Eczema in Hong Kong ISAAC Study from 1995 to 2015.
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