Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach.

Nat Commun · 2022 · PMC9780321 · PMID 36550114

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highly significantp < 10 −15actually significant

The baseline method ROTS that ignores longitudinal trends also performed well with an IQR mean pAUC of 0.941, while the difference to the best performing method RolDE was highly significant ( p < 10 −15 ).

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