Management of Clostridioides difficile infection in adults and challenges in clinical practice: review and comparison of current IDSA/SHEA, ESCMID and ASID guidelines.

78 The conclusion, however, recently from ESCMID was that adverse effects may be significant and probiotics may actually delay microbiome reconstitution after antibiotic treatment. 4 There are limited data regarding adjunctive probiotic therapy for a first episode or first recurrence of non-severe CDI and the nature and timing of administration has varied in the available studies.

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