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Reoxygenation Modulates the Adverse Effects of Hypoxia on Wound Repair.

Int J Mol Sci · 2022 · PMC9781139 · PMID 36555485

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In burns, α-SMA expression was highly significantly increased in the normoxia group at 13 d, while the hypoxic group showed a negligible increase, and the reoxygenation group also showed an increasing trend ( Figure 9 H), indicating that long-term hypoxia could inhibit angiogenesis at the wound, while reoxygenation could effectively increase angiogenesis and promote wound healing.

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