Differential impact of body mass index and leptin on baseline and longitudinal positron emission tomography measurements of the cerebral metabolic rate for glucose in amnestic mild cognitive impairment.

Front Aging Neurosci · 2022 · PMC9782536 · PMID 36570534

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However, when adjusted for cognitive decline (i.e., ΔADAS-cog 11) none of these associations remained significant, whereas cognitive decline was associated with widespread and highly significant rCMRgl declines within similar AD-typical brain regions (overlap illustrated in Figure 2 ).

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