Effects of total diet replacement programs on mental well-being: A systematic review with meta-analyses.

Interestingly, despite the majority of these four sub‐domains achieving significant increases in scores as listed above, the pooled estimates of the mental composite summary score did not achieve significance.

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Our final pooled SMD estimates for depression assessing change over time in independent samples without comparators found highly significant reductions in depression scores for all three time point comparisons: pre‐diet to mid‐diet; pre‐diet to post‐diet; and pre‐diet to follow‐up, with 192, 754, and 535 participants from 6, 22, and 17 independent samples, respectively (Table 3A ).

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