Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental Colitis.

By contrast, the same samples measured for OVA concentrations showed highly significant differences between all genotypes (log transformed concentration of Muc2 +/+ vs Muc2 +/- , -10.58 ± 0.06 vs -9.77 ± 0.24; P = .05; Muc2 +/+ vs Muc2 -/- , -10.58 ± 0.06 vs -8.06 ± 0.33; P = .0002; Muc2 +/- vs Muc2 -/- , -9.77 ± 0.24 vs -8.06 ± 0.33; P = .002) ( Figure 4 B ), indicating that loss of function of even 1 Muc2 allele significantly weakens intestinal barrier function.

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