Correlations were highly significant for the main cell types involved in CHIKV arthritis; T cells ( 56 – 58 ), monocyte/macrophages ( 45 , 51 , 55 ) and NK cells ( 59 ), and to a lesser extent neutrophils ( 54 , 60 ), regulatory T cells ( 61 , 62 ) and dendritic cells ( 13 ) ( Figure 3C ).
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Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model.
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