TIGIT blockade repolarizes AML-associated TIGIT⁺ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.

The GSE37642 and GSE12417 databases, both containing microarray-based gene expression data of patients with AML (n=136 and n=240 patients) showed that high CD163 expression was associated with poor prognosis, although the significance level reached only borderline significance ( figure 4D ).

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