Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions.

In combination with our previous findings from model of a rat with MCAO, we demonstrated that NDRG2 protein levels in ipsilateral tissue of MCAO models show an increasing trend over time, but the difference detected by western blot compared with the contralateral side is statistically significant, at least 8 h later, during which it is accompanied by astrocyte activation [ 8 ].

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