Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection.

Indeed, we observed an overall trend toward lower IgM levels in the rabbits that received GPC NPs, with IgM levels being significantly lower after the second immunization (median mean fluorescence intensity [MFI] of 67 versus 320, respectively; two-tailed Mann-Whitney U -test; p = 0.0022), consistent with observations that multivalent antigen presentation accelerates class-switching. 32 We used a previously described lentivirus-based pseudovirus assay to measure the induction of NAb responses. 19 No neutralization was induced after two immunizations ( Table S2 ).

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